Search results for "Startle reaction"

showing 3 items of 3 documents

GLRB allelic variation associated with agoraphobic cognitions, increased startle response and fear network activation: a potential neurogenetic pathw…

2017

Contains fulltext : 177350.pdf (Publisher’s version ) (Closed access) The molecular genetics of panic disorder (PD) with and without agoraphobia (AG) are still largely unknown and progress is hampered by small sample sizes. We therefore performed a genome-wide association study with a dimensional, PD/AG-related anxiety phenotype based on the Agoraphobia Cognition Questionnaire (ACQ) in a sample of 1370 healthy German volunteers of the CRC TRR58 MEGA study wave 1. A genome-wide significant association was found between ACQ and single non-coding nucleotide variants of the GLRB gene (rs78726293, P=3.3 x 10-8; rs191260602, P=3.9 x 10-8). We followed up on this finding in a larger dimensional AC…

0301 basic medicineMaleStartle responseReflex StartleQH301 BiologyGenome-wide association studyGene mutationAnxiety0302 clinical medicineCognitionReceptors GlycineGene FrequencyGermanyGWASHyperekplexiaGeneticsPanic disordermedicine.diagnostic_testStartleBrainFearGLRBAnxiety DisordersPsychiatry and Mental healthSchizophreniaUrological cancers Radboud Institute for Health Sciences [Radboudumc 15]Panic DisorderFemalemedicine.symptomPsychologyBDCRC0321 Neuroscience. Biological psychiatry. NeuropsychiatryClinical psychologyAdultGenotypeNDASQH426 Genetics03 medical and health sciencesCellular and Molecular NeuroscienceQH301Fear networkSpastic mousemedicineHumansGenetic Predisposition to DiseaseMolecular BiologyQH426AgoraphobiaAllelesNeurodevelopmental disorders Donders Center for Medical Neuroscience [Radboudumc 7]Panic disorderOther Research Radboud Institute for Health Sciences [Radboudumc 0]medicine.diseaseStartle reaction030104 developmental biologyMCPCase-Control StudiesMutationRC0321030217 neurology & neurosurgeryAgoraphobiaGenome-Wide Association StudyMolecular psychiatry
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Excitability of subcortical motor circuits in Go/noGo and forced choice reaction time tasks

2006

The size of the response to a startling auditory stimulus (SAS) may reflect the excitability of the reticulospinal tract. In this study, we examined whether there was any excitability change in the reticulospinal tract during preparation for execution of two types of choice reaction time task: a forced choice reaction time task (fCRT) and a Go/no-Go task (GnG). In 13 healthy volunteers we used three types of trials: control trials in which subjects were requested to perform ballistic wrist movements during fCRT or GnG tasks; test trials in which a SAS was presented with the visual cue, and baseline trials in which SAS was presented alone. Latency and area of the responses to SAS were measur…

AdultMaleVolitionReflex Startlemedicine.medical_specialtyMovementMotor programNeuropsychological TestsStimulus (physiology)Reticular formationChoice BehaviorEfferent PathwaysPhysical medicine and rehabilitationNeck MusclesReaction TimemedicineHumansEvoked PotentialsCerebral CortexBlinkingChoice reaction timeTwo-alternative forced choiceReticular FormationGeneral NeuroscienceMotor controlReticulospinal tractMiddle AgedStartle reactionFemaleCuesPsychologyNeurosciencePhotic StimulationPsychomotor PerformanceNeuroscience Letters
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Chapter 9 The effects of a prepulse on the StartReact phenomenon

2006

Publisher Summary This chapter presents a study to investigate whether the inhibitory effects of the prepulse are different in the condition of motor preparation with respect to that of unexpectancy and whether the inhibition of the startle reaction by a prepulse is associated with the inhibition of the StartReact phenomenon. The chapter demonstrates that the procedure could help in ascertaining whether reflex and volitional components are actually combined in the StartReact phenomenon. Eight healthy volunteers, six men and two women, aged between 25 and 52 years were investigated and the startle reaction was recorded with surface electrodes over the right orbicularis oculi muscle and, in t…

Motor taskReflexStimulus (physiology)Voluntary actionInhibitory postsynaptic potentialPsychologySternocleidomastoid muscleStartle reactionNeurosciencePrepulse inhibition
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